Tirzepatide, which is sold under the brand name Mounjaro, was studied in people without diabetes in three dosages: 5, 10 and 15 milligrams. Participants with obesity or who were overweight and took the 5-milligram dose lost an average of 35 pounds (16 killograms), those on the 10-milligram dose lost an average of 49 pounds (22 kilograms), and participants on the 15-milligram dose lost an average of 52 pounds (23.6 kilograms).
“Almost 40% of individuals lost a quarter of their body weight,” said coauthor Dr. Ania Jastreboff, codirector of the Yale Center for Weight Management in a briefing for the media.
“The middle range of weight loss for people in this new study was 49 pounds — 49 pounds is a lot,” said Dr. Robert Gabbay, chief medical officer of the American Diabetes Association. “It’s the range of weight loss that we typically think only possible through surgery.”
All in all, people without diabetes lost an average of 15% to 20.9% of their starting body weight over the course of the 72-week double-blinded, randomized clinical trial, which was published Saturday in The New England Journal of Medicine. Participants who got a placebo lost between 2.4% and 3.1% of their body weight, on average.
In comparison, studies on people with diabetes who used tirzepatide found they lost an average of 15% of their starting body weight, Gabbay said.
For the new study, weekly injections of tirzepatide were tested in more than 2,500 people without diabetes who had a body mass index (BMI) over 30 or who were over 27 BMI and had at least one weight-related health condition such as high blood pressure, high cholesterol or cardiovascular disease. A measure of a person’s height-to-weight ratio, a BMI of 25 or higher is considered overweight in adults.
At the start of the study, the participants had an average weight of 231 pounds (104.8 kilograms) and average BMI of 38.
People in the study also received counseling sessions to help them stay on a healthy diet with a daily 500-calorie deficit, as well as at least 150 minutes of physical activity each week. While that certainly helped, it does not explain the magnitude of the weight loss seen in the study, Gabbay said.
“The kind of weight loss that we see when people exercise and change their calorie intake is somewhere in the order of 5% to 7%,” he said. “This study showed a profoundly greater weight loss, far above what we would imagine with lifestyle changes.”