New blood test can spot more than 50 types of cancer – many hard to detect early

[ – 2021.11.02] The sooner most cancers are discovered, the better the odds they can be successfully treated. Mayo Clinic participated in research on a test that can detect more than 50 cancers. Doctors call it a game-changer.

“My dad, he was a healthy guy. He didn’t have any known risk factors for cancer,” Dr. Julia Feygin said. Feygin lost her 40-year-old father to pancreatic cancer when she was 13. Diagnosed at stage three, he lived for nine more months.

“I strongly believe that purpose can be found in everything that happens,” Feygin said.

She’s now part of a team at a Menlo Park, California-based company called GRAIL that’s introducing the blood test, called Galleri. She says can it catch hard-to-detect, aggressive and often deadly cancers like pancreatic, ovarian and esophageal.

“If cancers can be detected early, we can dramatically improve patient outcomes,” Feygin said.

Feygin explains that our blood contains a DNA signature. The blood test tracks the DNA a cancer cell sheds.

“We can find and sequence these tiny bits of tumor-derived DNA in the blood and, based on the patterns we see, we can reveal if there is a signal for cancer present. We can predict with very high accuracy where in the body this cancer signal is coming from,” Feygin said.

The results are sent back to the health care provider in 10 business days.

An interventional study that included Mayo Clinic with 6,600 participants returned 29 signals that were followed by a cancer diagnosis.

Another study found a less than 1% false positive rate.

There are some caveats on who can get the test.

“It’s intended to be used for people at an elevated risk for cancer. This can be something as simple as age,” Feygin said.

Right now, the test is by prescription-only. Insurance doesn’t cover it. You would pay out of pocket with a current cost of $949.

“In the year 2021, this is so far beyond anything else we’ve been able to do. This is a game-changer,” said Dr. Greg Plotnikoff.

He has prescribed the test for patients and family members with risk factors, saying cancers caught early are in more treatable stages.

He also chose to screen himself, since he is over 60.

GRAIL is still working on full FDA approval. You can ask your doctor to request the test.

Before the end of the year, Galleri will be available at Mayo Clinic locations in Rochester, Minnesota, Jacksonville, Florida, and Phoenix. It will also be available at Mayo Clinic Health System sites in southern Minnesota and Wisconsin.

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